| Story/Game/Design/Project Leads: | Sean Clark |
| Michael Stemmle |
| Lead Programmer: | Michelle Hinners |
| Systems Programmer/Additional Design: | Randy Stevenson |
| Game Scripting/Additional Design and Dialogue: | Ryan Danz |
| Richard Sun |
| Game Scripting: | Karen Petersen |
| David Graham McDermott |
| Audio Programmer: | Geoff Gates |
| Lead Artist: | Chris Miles |
| 3D Backgrounds: | Kim Batestreri |
| Eddie Del Rio |
| Bernard Eral |
| Shayne Herrera |
| Kathy Hsieh |
| Paul Pierce |
| Jacob Stephens |
| 3D Backgrounds/Cinematic Lighting: | Kristen Russell |
| Cinematic Lighting/Art Tool Specialist: | Daniel Colon, Jr. |
| Lead Animator/3D Animation: | Marc Overney |
| 3D Animation/Character Models/Animation Setup: | Christina Boyle |
| Lisa Wong |
| 3D Animation: | Yang Ja (Yoko) Ballard |
| David Bogan |
| Sandy Christensen |
| Cathy Feraday |
| Ryan Gong |
| Roger Liu |
| Armando Lluch |
| Razmig Mavlian |
| Yuhon Ng |
| Rebecca Perez |
| Charlie Ramos |
| Chris Schultz |
| David Weinstein |
| Joseph White |
| Kameron Gates |
| 3D Object Models/Textures: | Tim Tao |
| Textures: | Nathan Stapley |
| Molly Mendoza |
| Michelle Sullivan |
| Post-Production Visual Effects: | Josef Richardson |
| Mike Terpstra |
| Lead Technical Artist: | Alisha Piccirillo |
| Technical Artists: | Sean Marr |
| Daryl Smolen |
| Concept Art: | Yang Ja (Yoko) Ballard |
| Eddie Del Rio |
| Kathy Hsieh |
| Chris Miles |
| Nathan Stapley |
| Production Manager: | Linda Villalobos Grisanti |
| Production Coordinator: | Christopher Tuite |
| Installer/Launcher Programmer: | Joe Ligman |
| Tools Programmers: | Steve Dykes |
| Charlie Smith |
| Voice Producer and Director: | Darragh O'Farrell |
| Voice Production Supervisor: | Peggy Bartlett |
| Voice Editors: | Cindy Wong |
| Hans Larson |
| Coya Elliott |
| Music Supervisor: | Clint Bajakian |
| Music Composers: | C. B. Studios, Inc. |
| Michael Land |
| Peter McConnell |
| Anna Karney |
| Michael Lande |
| Sound Department Manager: | Jeff Kliment |
| Sound Development Supervisor: | Larry the O |
| Sound Department Coordinator: | Malena Slettorn |
| Senior Sound Designer: | Nick Peck |
| Sound Designers: | J. White |
| Jory K. Prum |
| Michael Frayne |
| Stan Weaver |
| David Levison |
| David Wayne Collins |
| Andrew Cheney |
| Voice Cast | |
| Guybrush Threepwood/Duck/Monkey 4: | Dominic Armato |
| Elaine Marley-Threepwood: | Charity James |
| Charles L. Charles/LeChuck/Pirate C: | Earl Boen |
| Ozzie Mandrill: | Nick Tate |
| Admiral Ricardo Casaba/Pirate 3: | Daryl Kurylo |
| Bagel the LUA Bar Patron/Heckler/Pegnose Pete/Pirate 6: | Tom Kane |
| Bank Manager/Gunner/Simkins/Pirate 5: | Paul Eiding |
| Brittany the Bank Teller: | Maria Bamford |
| Caricature Artist/Ned the SCUMM Bar Dart Player: | Peter Lurie |
| Carla the Swordmaster: | Pamela Tyson |
| Castenada the Chess Player/Judge Kahuna/Parrot/SCUMM Bartender: | Rob Paulsen |
| Clive the Jambalaya Tourist/Meathook: | Cam Clarke |
| Dainty Lady Figurehead: | Pamela Segall |
| Daisy the Knuttin Atoll Pirate/Mabel the Jambalaya Tourist: | Tress MacNeille |
| Deadeye Dave/Thrawtle the Lucre Lawyer: | Tom Kenny |
| Digg the Lucre Lawyer/Judge Edd: | Joe Alaskey |
| Drunk: | Jim Ward |
| Estaban/Judge Tripps/LUA Bar Chef/Pirate 1: | Jess Harneil |
| Freddie the Walking Stick Maker: | Lewis Arquette |
| George the SCUMM Bar Dart Player/Stan: | Pat Fraley |
| Harbor Mistress: | Lauri Johnson |
| Hellbeard: | Nick Jameson |
| Herman Toothrot/Pirate 2/Pirate B: | Waily Wingert |
| Ignatius Cheese: | W. Morgan Sheppard |
| Inspector Canard: | Peter Jessop |
| Jojo Jr./Salty the Bait Shop Owner: | John Mariano |
| Jumbeaux LaFeet/Mungle the Pirate Student: | Charles Adler |
| LUA Bar Waitress/Timmy the Monkey: | Debi Derryberry |
| Manatee Operator/Starbuccaneer's Clerk: | Jim Wise |
| Marco de Pollo: | Jeff Glen Bennett |
| Monty the Jambalaya Tourist/Three-Headed Monkey: | Phil Proctor |
| Miss Rivers: | Eddie McClurg |
| Murray/Santiago the Chessplayer Pirate: | Denny Delk |
| Otis/Monkey/Pirate A: | S. Scott Bullock |
| Perfume Spritzer/Pirate 4: | Neil Ross |
| Planet Threepwood Waitress: | Heidi Shannon |
| Reverend Rasputin: | Keith Szarabajka |
| Tony DiBoulda the Catapult Operator: | James Ward |
| Voodoo Lady: | Leilani Jones Wilmore |
| Whipp the Lucre Lawyer: | Bob Bergen |
| Yangja the Pirate Student/Yoshen the LUA Bar Patron: | Grey Delisle |
| Monkey 3: | Darryl Kurylo |
| Lead QA Tester: | John Buzolich |
| QA Testers: | Jo Ashburn |
| Michael Blair |
| Louis Bliemeister |
| Leyton Chew |
| Brandy M. Childs |
| Stephen Hancock |
| Peter Lim |
| Ricardo Liu |
| Chris Snyder |
| Chris Susen |
| Joseph John Talavera II |
| Quentin Westcott |
| International Lead Tester: | Jeff Sanders |
| Compatibility Supervisor: | Chip Hinnenberg |
| Senior Compatibility Technician: | Lynn Taylor |
| Compatibility Technicians: | G. W. Childs |
| Darryl Cobb |
| Jim Davison |
| Doyle Gilstrap |
| Dan Martinez |
| John von Eichhorn |
| Manager of International Production: | Darren Hedges |
| Localization Coordinator: | Shara Miller |
| Manual: | Jo Ashburn |
| Christopher Inclenrock |
| Mollie Boero |
| Very Special Thanks: | George Lucas |
